In this issue of Child and Adolescent Psychiatric Clinics, guest editors Drs. Scott Liebowitz, Serena Chang, and Natalia Ramos bring their considerable expertise to the topic of Transgender and Gender Diverse Children and Adolescents. Top experts in the field cover key topics such as assessment of gender diverse children and gender diverse and trans adolescents; complex psychiatric histories and gender diverse/transgender youth; neurodiversity and transgender/gender diverse youth: the co-occurrence; individual affirming care; psychosocial family treatments and navigating family dynamics; and more